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How Pain Can Change Your Brain

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Chronic pain isn’t just a nag. It can make day-to-day life downright miserable.

It’s hard to focus on anything when you’re in pain. New research tells us why.

A recent study, published in the Journal of Neuroscience, sheds some light on exactly what goes on in the brain while folks are in constant pain [1]…

Can pain change the brain? If so, can the changes be reversed?

For this study, researchers recruited eighteen adult patients with chronic low back pain.

Before they were given treatment for their pain, each patient was subject to a functional MRI (fMRI).

A control group of sixteen healthy, pain-free participants was also given an fMRI.

Here’s what happened:

The first thing researchers noticed was that a prominent region in the frontal cortex – called the dorsolateral prefrontal cortex (DLPFC) – was thinner in the lower back pain group than that of the pain-free group.

Next, during the brain scan, participants were asked to perform a mental task. They had to pick out a visual target from other characters.

Both groups performed the task equally well. The major difference was that those in pain had several more brain regions that were activated, including the DLPFC.

Once the brain scan data was collected, the patients received treatment for their pain.

Six Months Later

Post-treatment, the majority of patients reported being pain free.

Researchers then gave each one a new fMRI to see what changes occurred in the brain, if any.

It turns out that the thickness of the DLPFC increased in EVERY patient who reported an improvement in his or her pain.

Then, when performing the same mental task from the first fMRI, these former pain patients showed a significant decrease in brain activation than they did while in pain.

In fact, their brain scans looked like those of the control group.

New Horizons in Pain Management?

I found this study to be very interesting for two reasons…

1. It shows us that healing the body also heals the mind (quite literally).

2. It begs the question… could a focus on changing the mind first (instead of the body through invasive surgery or drugs) eventually become the preferred method of treatment?

More research needs to be done, to be sure. I just hope it gets done quickly.

Chronic pain sufferers may be the most under serviced…and downright mistreated people being herded through the health care systems of the world.

And despite all the cutting-edge research being done, (for example, we now know that emotions have a large effect on how intensely you feel pain. As well, it’s proven that stress and anxiety can change the structure of your brain for the worse) it seems like the day where doctors will turn to the mind as the first and preferred option for pain management is still far away.

What do you think? I’d love to hear your opinion!

[1] Seminowicz DA, et al., “Effective treatment of chronic low back pain in humans reverses abnormal brain anatomy and function.” J Neurosci. 2011 May 18;31(20):7540-50.

Tags: back pain, brain structure, pain
  • Janie M.

    This is very interesting and explains a lot.  I have in pain for a long time now and do find it really hard to concentrate.  It hurts. Thanks for the very informative article.  Keep them coming!!!

  • Thegooselady1940

    I do hope they make progress in this area. I would love to be pain free but don’t think it will happen in my lifetime.  People that don’t have pain never realize what it is like for the people that have chronic pain. They just think we are pretending. I tell my husband that if he just had the pain I have daily for one day, then he wouldn’t be so judgmental.

  • Thegooselady1940

    I do hope they make progress in this area. I would love to be pain free but don’t think it will happen in my lifetime.  People that don’t have pain never realize what it is like for the people that have chronic pain. They just think we are pretending. I tell my husband that if he just had the pain I have daily for one day, then he wouldn’t be so judgmental.

  • http://www.exploringthemind.com Michael Lovitch

    I understand you definitely aren’t pretending.  Have you tried the Feldenkrais method?

  • Mark

    what is not clear to me are the associations (that seem to be all the rage) between brain regions being lit/unlit or this color shade/intensity/hue vs that color shade/intensity/hue and “healing”, or any other diagnostic. here, as so much elsewhere in medicine, the method is to head-count (sorry, lol), for what’s under the fat part of the curve, pronounce it the standard of health that should be aspired to…in a classroom setting, this would be shooting for C averages……   

  • Phonelady

    I have been living with back pain for several years.  Within the past four years I have had two spinal fusion surgeries, 1 proceedure where the surgeon scraped my disc, have had 3 different physical therapies,  yoga excersie. accupuncture, massage therapy and still having the back pain.  I am currently reading Dr Sarno’s “TMS, Healing The Back Pain”.  He has treated several patients with back pain. His theary is that the pain is caused byrepressed anger, axiety, and fear. I recomend evryone with chronic back pain  read this book.

  • http://www.exploringthemind.com Michael Lovitch

    Hi… I remember reading Dr. Sarno’s book a long time ago when I was in my early 20′s and this might of been when I truly became interested in mind body healing.  His evidence is compelling. 

  • http://www.facebook.com/gale.boulton Gale Edward Boulton

    The old joke about the Maharishi at the dentist is not off the mark: Offered Novocaine, the great Guru said, “No, I will transcenddental medication.” 
    When undergoing angioplasty in 1989, where an occluded coronary artery is bumped open with a pointy balloon catheter inserted in the aorta at the groin, I tried softly omming, going into alpha, which definitely reduced the pain about 50% as the balloon was inflated. My cardiologist asked, “Are you humming?” I replied, “No, Omming, it reduces the pain.”  I’m sure he automatically thought, “some New Age nonsense.”  I even wrote him a letter about it -no response.  It should be Standard Operating Procedure by now.Willhelm Reich and later Alexander Lowen with his bioenergetics proved there are specific spots in the brain which reflex to specific places in the body and can be used as switches to turn off pain. Reich was so effective, he was imprisoned as a quack and died there.People with chronic migraines are using biofeedback, without the meter, by simply sitting comfortably, hands in lap, and visualizing their hands getting warm by  blood draining from their brains, thus reducing cranial pressure and disappearing the migraine.If FEAR is just False Evidence Appearing Real, then It ONLY HAS THE POWER YOU GIVE IT!  Gale E. Boulton   

  • http://www.facebook.com/profile.php?id=74201608 Mel Fox

    I started a desk job a year ago and as time progressed I became less and less engaged in my work. The work was interesting but I just couldn’t keep up. Then I went to a chiropractor for lower back pain and 4 treatments in I’ve noticed a real difference in my attitude. I’m more willing to do house work and I’ve become more productive at work. If you work toward a healthier body, a healthier mind will follow! 

  • http://www.losangeleslimoca.com Andrew symonds

    What an educative post this is. I still have a lot of pain in my backbone. I took lot of treatment but not save still now. What you think about me?

  • http://www.socialskateboarding.com/ Nathan Smith

    It should be Standard Operating Procedure by now.Willhelm Reich and
    later Alexander Lowen with his bioenergetics proved there are specific
    spots in the brain which reflex to specific places in the body and can
    be used as switches to turn off pain. 

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